Antabuse (Disulfiram)

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Brand Names: Antabuse
Generic Name: Disulfiram
Dosage: 250mg, 500mg

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Description

Antabuse is a brand name of Disulfiram which is used for the treatment of the alcohol abuse. The mechanism of the action consists in the increase of the sensitivity of the body to alcohol and a formation of the rejection of ethanol.

In the body, ethyl alcohol goes through several stages of metabolism. If a process of metabolism of ethanol is broken on one of the stages, the side effects can be caused.

Antabuse blocks certain enzyme produced by liver which favors the final breaking of alcohol in the body. Inhibiting the production of this enzyme in the liver, it stops the process of breaking ethyl alcohol into carbon dioxide and water on the stage of the acetic aldehyde that is a histic poison. The increased amount of acetic aldehyde causes a severe intoxicant in the human body.

The intoxication causes unpleasant, painful sensations: difficult breathing, head noises, fear, shivers, nausea, dizziness, tachycardia, pain in the chest, muscle weakness, anxiety, and others.

The more often these symptoms appear, the faster a fear before consuming alcohol appears. Netagive emotions inhibit the positive effects which have been caused by the beverage drinks before, and the human has a rejection of ethanol.

Using Antabuse, it is possible to effectively treat alcohol abuse regardless of how long a patient abuse alcohol.

What should you know before taking Antabuse for the first time?

If you decided to take Antabuse to treat alcohol abuse, it is necessary to have the body cleansing. If there are a lot of ethanol in the blood, the use of Antabuse can cause severe side effects which will bother a complete medical therapy.

Before using the medicine, a patient should avoid beverage drinks for 5-7 days.

How to take Antabuse?

The treatment of the alcohol abuse should be started from the maximal dose of Antabuse 500 mg per day. The medicine is used once, at any time, dissolving the tablet in the water. In 7 days, it is recommended to conduct disulfiram-alcohol-test: a patient should take 30 ml of vodka after the use of one tablet of Antabuse 500 mg. If the reaction to alcohol is weak, it is recommended to repeat the test increasing the dose of alcohol by 10-20 ml in 2-3 days. After having the body reaction to ethanol, the treatment can be called successful, and a patient is recommended to use the maintaining dose of Antabuse 200 mg per day.

The treatment of the alcohol abuse can last for a long time, within 1-2 years. In case of the prolonged use, Disulfiram does not cause a medical addiction, and the body does not produce a resistance to the action of this medicine.

Contraindications for the use

Antabuse will definitely cause severe side effects during the alcohol consumption. The medicine itself is indifferent, however, there is a big list of the contraindications during which this medicine is not recommended, for the sake of patient.

Antabuse is strictly contraindicated during:

  • severe diseases of the cardiovascular system
  • severe ophthalmic diseases
  • diseases of the ear
  • asthma
  • pulmonary tuberculosis
  • severe liver disease
  • diabetes
  • irregularities in the thyroid
  • exacerbation of gastric and duodenal ulcers
  • the presence of malignancy.

Women during pregnancy or lactation are strictly contraindicated to take Antabuse because this medicine can cause severe pathologies of a child. Patients over 60 years can take Antabuse only by the doctor’s recommendation, if there are no contraindications. Patients of senior age are recommended to have a therapy on an outpatient therapy, under the doctor’s supervision.

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