Doxycycline is a semi-synthetic antibiotic from the group of tetracycline. It provides bacteriostatic action to pathogenic and potentially pathogenic microorganisms.
The mechanism of action of Doxycycline does not consist in the destruction of the cellular structure and a fast inhibition of the bacteria activity. Penetrating into the body, Doxycycline inhibits synthesis of protein in the microbial cell, so that bacteria lose the ability to develop and grow.
This antibiotic acts only on the intracellular originators and almost does not affect the activity of the useful microflora in the gastro-intestinal tract. The basic advantage of Doxycycline is a prolonged action unlike other tetracycline antibiotics. And a strong bacteriostatic effect is achieved in lower doses, so the toxicity for the body is lower.
Use of Doxycycline
Doxycycline is prescribed during infectious processes which has been caused by pathogenic gram-positive and gram-negative microorganisms:
- Diseases of infectious inflammatory respiratory tract and ENT organs.
- Infectious processes of the digestive tract organs
- Diseases of the skin and soft tissues
- Inflammation of infectious origin in the urinary tract organs
- Genital infections
The medicine is used for the purposes of the prevention of post-operative purulent complications, and medical abortions.
Doxycycline is used according to the standard scheme for most infections, if the patient does not have contraindications for the use. If the patient has contraindications, an individual approach to the treatment and dosage are recommended.
Scheme of the use of Doxycycline
Doxycycline should be taken during or after food, with a glass of water. Taking the medicine this way, a risk of the irritation of mucosa of the gastro-intestinal tract is reduced.
The daily dose of Doxycycline can be used at once or can be divided into two times, in case of the side effects in the GIT. The standard daily dose of Doxycycline is 100-200 mg depending on the severity of the disease.
In case of the severe infectious processes (chlamydia, urethritis, and others), the dose of Doxycycline is usually not increased but the length of the treatment is. The length of the use is 5-10 days during the infections of the middle severity, and in case of the severe infectious processes – 10-14 days.
Doxycycline seldom causes the side effects than other tetracycline, but patients still may have unwanted body reactions: nausea, vomiting, weight loss, stomachache, sweating, and skin rash.
If the precautions are not observed during the prolonged use of Doxycycline, a development of candidiasis of the skin and mucosa can happen. To avoid this, one tablet of Fluconazole should be used every 3 days.
The side effects are well tolerated and do not prevent the effective treatment of the infectious diseases.
Using Doxycycline in high doses can cause neurotoxic reactions: affection of the liver, vomiting, spasm, increased intracranial pressure, and severe allergic reaction.
In case of the overdose symptoms, it is necessary to stop the treatment, have a stomach lavage, and begin a symptomatic therapy.